COVID-19 Vaccine Effectiveness in Nursing Home Residents
The article discusses the effectiveness of COVID-19 vaccination in preventing SARS-CoV-2 infection among nursing home residents. The study analyzed data from November 20, 2022, to January 8, 2023, and found that being up-to-date with COVID-19 vaccination was associated with a 31.2% reduction in the risk of SARS-CoV-2 infection compared to not being up-to-date.
The study defined "up-to-date" as having received a bivalent vaccine dose or completing a primary series less than 2 months earlier. The analysis included data from over 9 million resident-weeks and found that the crude infection rate was significantly lower among residents who were up-to-date with their vaccination (12.3 per 1,000 resident-weeks) compared to those who were not up-to-date (16.6 per 1,000 resident-weeks).
The study used a zero-inflated negative binomial mixed model to estimate the rate ratio (RR) and vaccine effectiveness (VE). The results showed that being up-to-date with COVID-19 vaccination was associated with a significantly reduced risk of SARS-CoV-2 infection (RR: 0.69, 95% CI: 0.67-0.71).
The article concludes that staying up-to-date with COVID-19 vaccination is crucial for preventing SARS-CoV-2 infections among nursing home residents. The findings emphasize the importance of ongoing vaccination efforts in this vulnerable population.
Key statistics from the study include:
- 31.2% reduction in the risk of SARS-CoV-2 infection among residents who were up-to-date with their vaccination
- Crude infection rate: 12.3 per 1,000 resident-weeks among up-to-date residents, compared to 16.6 per 1,000 resident-weeks among not-up-to-date residents
- Rate ratio (RR): 0.69 (95% CI: 0.67-0.71)
- Vaccine effectiveness (VE): 31.2% (95% CI: 29.1-33.2)